New camera detected for help Cell , Cancer cell
New camera detected for help Cell
By imitating the complex visual system of a butterfly, the researchers have created a new camera detected for help Cell Cancer cell camera that provides a near-infrared image along with a conventional color image to the surgeon,
which can be labeled as cancerous cells that appear under fluorescently bright surgical light Does. The new camera is designed to help remove all cancerous cells without harming healthy tissue, making it less likely that cancer will spread and reduce the need for many surgeries.
Viktor Gwave, leader of the research team from the University of Illinois at Urbana-Champaign, said, “Instead of putting together the commercially available optics and sensors to create cameras for image-directed surgeries,
we used visual systems of nature Saw.” “Morpho butterfly, whose eyes understand the nanostructure that understands multi-spectral information, can achieve both near-infrared and colorful information simultaneously.”
In the Optical Society’s Journal for High Effect Research, researchers show that their bicycle camera can detect tumors in animals and is useful for evaluating the level of breast cancer in people.
The new camera provides very sensitive fluorescence detection under the light of the standard operating room, less than the AA battery, and it can be manufactured for around $ 20
“During surgery, it is necessary that all cancerous tissues have been removed, and we have created the imaging stage which can help the surgeon to do this in any hospital around the world because it is small, compact and affordable,” Gwave said. “Although we have addressed the instrumental side,
however, for our comprehensive technology approved for use in fluorescent markers and people targeted for cancer, our techniques are necessary. Many of these are still clinical trials, So we should see progress in this area soon. ”
Learning from nature
The new camera makes a lot of improvements on today’s cameras, which are available in the U.S. to see fluorescent markers during surgery. Approved by the Food and Drug Administration (FDA). Many existing near-infrared cameras lack the sensitivity to detect fluorescence markers under surgery settings, so the cell light should be dimmed to see the fluorescence.
Another problem with today’s infrared imager is that the fluorescence image is not always properly aligned, or the core bastard, it is produced from the tissue. This is because FDA approved equipment uses many optical elements, such as beam splitter and relay lenses,
to separate visible and infrared wavelengths so that each detector can be sent separately. Light temperature changes in the room can affect optics in these devices, which are the image missiles.Those surgeons can remember cancerous tissues while reducing unnecessary health issues.
Missael Garcia, a researcher at the University of Illinois at Urbana-Champaign, said, “We felt that the problems of today’s infrared imager may reduce by using nanostructures like morpho butterfly.” “His mixed eyes include photoreceptors located next to each other, such that each photoreceptor understands the different wavelengths of light in a manner that is internally coated.”
new camera detected for help Cell Cancer cell
The new camera enables the collection of color and near-infrared fluorescence information on an imaging device, by combining different nano social structures with an array of photodetectors,
A setup similar to the butterfly eyes can be used. Integrating detectors and imaging optics in a single monocular sensor keeps small, affordable and insensitive devices for temperature changes.
The design specifically solves the sensitivity problem by allowing each pixel to take the number of photons needed to create an image. Since the light that is visible in the lab is high, it does not take long to create a visible-wavelength image to see the anatomy.
On the other hand, because fluorescence is generally slow, it takes more time to gather enough photons to create a lucrative image.By changing the time of exposure to allow each pixel to identify photons, a bright fluorescence image can be made without undermining the color of the tissue.
Preclinical and clinical testing
Researchers have tested their new instrument on the mouse model, which develops smooth breast cancer. This means that the exact location where cancer will increase is unknown, such as the number of cancerous cells.
Tied to cancer cells using fluorescent labels, researchers showed that their biomass imager approved FDA-approved image-directed surgery with sensitivity and sensitivity crossing state-of-the-art infrared cameras with the ability to detect tumors.
The researchers also tested the capability of their infrared camera to identify lymph nodes in 11 patients with breast cancer in Washington University School of Medicine at St. Louis. Because lymph node is one of the primary areas where breast cancer spreads,
surgeons investigate them to determine cancer phase. Patients were injected with the FDA-approved indocyanine green fluorescent dyes which deposited in lymph nodes in an idyllically And then the fluorescence images were displayed on a screen by the biocide imager or were presented on the black goggles worn by the surgeons.
“We showed that, according to bright surgical illumination, compared to the currently approved imagers for infrared image-guided surgery, our instrument was 1000 times more sensitive to fluorescence,” said Gwave “because biological imager tissues reveal deep fluorescence Because it increases the process of identification of the lymph node and helps the surgeons find lymph nodes Which cannot be seen in terms alone. ”
According to the researchers, bioinspired imager will be useful for the removal of various types of cancers, including melanoma, prostate cancer and head and neck cancers. Due to its small size, it can also be integrated into an endoscope for cancer during colonoscopy, for example
Garcia said, “One big advantage of our instrument is its compact size” “We tested our equipment in a hospital where space was tight and it did not intrude on the surgical workflow.”
Researchers are now building a start-up company to make their first imager commercial and working with an FDA to prepare a clinical trial in which the surgeon with FDA approved new imagers Can compare diagnostic decisions made. Engaged
new camera detected for help Cell Cancer cell